Table 3.
Crude and multivariable adjusted odds ratio (OR) for reduced LVEF after 4 months.
| OR | 95% CI | p value | |
|---|---|---|---|
| Univariate analyses | |||
| High dsDNA levels on day 11 | 3.7 | 2.0–6.8 | <0.001 |
| Age, per year | 1.00 | 0.97–1.02 | 0.760 |
| Male gender | 3.7 | 1.4–9.7 | 0.009 |
| Time, symptoms to PCI (ln), per SD | 1.4 | 1.0–1.9 | 0.026 |
| Anterior MI | 3.6 | 2.0–6.5 | <0.001 |
| Ischemic postconditioning | 0.9 | 0.5–1.5 | 0.641 |
| Multivessel disease | 0.9 | 0.5–1.6 | 0.667 |
| Peak CRP (ln), per SD | 3.1 | 2.1–4.6 | <0.001 |
| CRP after 4 months (ln), per SD | 1.5 | 1.2–2.0 | 0.006 |
| Peak troponin T (ln), per SD | 10.5 | 5.6–20.0 | <0.001 |
| Multivariable analyses | |||
| Model 1 | |||
| High dsDNA levels on day 11 | 3.0 | 1.6–5.7 | 0.001 |
| Male gender | 2.9 | 1.0–8.3 | 0.048 |
| Time, symptoms to PCI (ln), per SD | 1.5 | 1.1–2.1 | 0.022 |
| Anterior MI | 3.0 | 1.6–5.8 | 0.001 |
| Model 2 | |||
| High dsDNA levels on day 11 | 2.1 | 0.99–4.33 | 0.052 |
| Male gender | 3.1 | 0.95–10.09 | 0.061 |
| Time, symptoms to PCI (ln), per SD | 1.5 | 1.0–2.2 | 0.042 |
| Anterior MI | 2.8 | 1.3–5.9 | 0.008 |
| Peak CRP (ln), per SD | 2.2 | 1.4–3.4 | <0.001 |
| CRP after 4 months (ln), per SD | 1.4 | 0.96–1.95 | 0.085 |
| Model 3 | |||
| High dsDNA levels on day 11 | 1.4 | 0.6–3.0 | 0.442 |
| Male gender | 2.2 | 0.6–7.2 | 0.212 |
| Time, symptoms to PCI (ln), per SD | 1.3 | 0.9–1.9 | 0.215 |
| Anterior MI | 1.2 | 0.5–2.6 | 0.692 |
| Peak troponin T (ln), per SD | 7.9 | 3.9–15.8 | <0.001 |
Reduced LVEF is defined as LVEF ≤ 49% measured by CMR 4 months after STEMI. 1>median (366 ng/ml). CI: confidence interval. CRP: C-reactive protein. dsDNA: double-stranded deoxyribonucleic acid. ln: natural logarithm. MI: myocardial infarction. PCI: percutaneous coronary intervention. SD: standard deviation.