Table 2.
Univariate and multivariate analyses for identifying the risk factors of overall survival in 156 HCC patients.
| Group | Univariate | Multivariate (gender and sex adjusted) | ||||
|---|---|---|---|---|---|---|
| HR | P | 95% CI | HR | P | 95% CI | |
| Gender | ||||||
| Male vs. female | 1.315 | 0.411 | 0.685-2.524 | |||
| Age (years) | ||||||
| ≤50 vs. >50 | 0.754 | 0.155 | 0.510-1.113 | |||
| Tumor diameter (cm) | ||||||
| ≤5 vs. >5 | 3.060 | <0.001 | 2.038-4.595 | 1.706 | 0.021 | 1.085-2.684 |
| Differentiation | ||||||
| Well vs. moderate & poor | 1.886 | 0.008 | 1.184-3.005 | 1.567 | 0.068 | 0.968-2.538 |
| AFP (ng/mL) | ||||||
| ≤50 vs. >50 | 1.799 | 0.005 | 1.191-2.716 | 1.448 | 0.095 | 0.937-2.235 |
| Liver cirrhosis | ||||||
| Yes vs. no | 1.010 | 0.963 | 0.654-1.561 | |||
| Portal vein invasion | ||||||
| Yes vs. no | 2.068 | 0.001 | 1.357-3.151 | 1.919 | 0.007 | 1.196-3.078 |
| HBsAg | ||||||
| Yes vs. no | 2.340 | 0.011 | 1.217-4.499 | 1.279 | 0.494 | 0.632-2.587 |
| TNM | ||||||
| I-II vs. III-IV | 4.468 | <0.001 | 2.950-6.766 | 2.393 | 0.001 | 1.445-3.963 |
| Metastasis | ||||||
| Yes vs. no | 3.016 | <0.001 | 1.917-4.745 | 1.304 | 0.327 | 0.767-2.219 |
| CKS2 expression | ||||||
| High vs. low | 5.668 | <0.001 | 2.943-10.916 | 2.088 | 0.014 | 1.161-3.754 |
CKS2: cyclin-dependent kinase regulatory subunit 2; TNM: tumor node metastasis; AFP: alpha-fetoprotein. Bold: P < 0.05.