Table 3.
Univariate and multivariate analyses for identifying the risk factors of disease-free survival in 156 HCC patients.
| Group | Univariate | Multivariate (gender and sex adjusted) | ||||
|---|---|---|---|---|---|---|
| HR | P | 95% CI | HR | P | 95% CI | |
| Gender | ||||||
| Male vs. female | 1.230 | 0.498 | 0.675-2.240 | |||
| Age (years) | ||||||
| ≤50 vs. >50 | 0.746 | 0.125 | 0.513-1.085 | |||
| Tumor diameter (cm) | ||||||
| ≤5 vs. >5 | 2.622 | <0.001 | 1.782-3.860 | 1.434 | 0.131 | 0.898-2.288 |
| Differentiation | ||||||
| Well vs. moderate & poor | 1.486 | 0.074 | 0.962-2.295 | |||
| AFP (ng/mL) | ||||||
| ≤50 vs. >50 | 1.660 | 0.012 | 1.120-2.460 | 1.403 | 0.108 | 0.929-2.119 |
| Liver cirrhosis | ||||||
| Yes vs. no | 0.903 | 0.642 | 0.588-1.387 | |||
| Portal vein invasion | ||||||
| Yes vs. no | 1.565 | 0.025 | 1.057-2.315 | 1.614 | 0.038 | 1.028-2.536 |
| HBsAg | ||||||
| Yes vs. no | 2.088 | 0.021 | 1.118-3.898 | 1.216 | 0.574 | 0.615-2.403 |
| TNM | ||||||
| I-II vs. III-IV | 4.030 | <0.001 | 2.697-6.022 | 2.702 | <0.001 | 1.608-4.539 |
| Metastasis | ||||||
| Yes vs. no | 2.370 | <0.001 | 1.531-3.668 | 0.846 | 0.534 | 0.499-1.434 |
| CKS2 expression | ||||||
| High vs. low | 2.210 | 0.003 | 1.316-3.711 | 2.511 | 0.002 | 1.414-4.458 |
CKS2: cyclin-dependent kinase regulatory subunit 2; TNM: tumor node metastasis; AFP: alpha-fetoprotein. Bold: P < 0.05.