Table 3.
Univariate and multivariate Cox regression analysis of survival among patient characteristics.
| Variable | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| HR 95% CI | p value | HR 95% CI | p value | |
| Gender male vs. female | 0.76 (0.47–1.25) | 0.285 | ||
| Age (year) ≤58 vs. >58 | 0.82 (0.57–1.19) | 0.298 | ||
|
| ||||
| KPS | 0.321 | |||
| 80 vs. 90 | 0.93 (0.52–1.66) | 0.802 | ||
| 80 vs. 100 | 1.67 (0.67–4.21) | 0.273 | ||
|
| ||||
| Child-Pugh score | 0.001 | |||
| 5 vs. 6 | 1.84 (1.19–2.83) | 0.006 | ||
| 5 vs. ≥7 | 2.52 (1.49–4.26) | 0.001 | ||
|
| ||||
| BCLC stage | <0.001 | <0.001 | ||
| A vs. B | 1.51 (0.92–2.48) | 0.106 | 1.26 (0.68–2.31) | 0.460 |
| A vs. C | 3.30 (2.00–5.44) | <0.001 | 3.68 (1.87–7.22) | <0.001 |
|
| ||||
| HBV negative vs. positive | 0.99 (0.64–1.51) | 0.950 | ||
| AFP (IU/ml) ≤28.1 vs. >28.1 | 1.79 (1.17–2.73) | 0.007 | ||
| Tumor thrombus (no vs. yes) | 2.69 (1.76–4.11) | <0.001 | ||
| LNM (no vs. yes) | 1.82 (1.10–3.01) | 0.020 | ||
| TACE (no vs. yes) | 1.13 (0.78–1.65) | 0.514 | ||
| RFA (no vs. yes) | 0.55 (0.26–1.18) | 0.125 | ||
| Tumor size (cm) ≤5.0 vs. >5.0 | 2.44 (1.68–3.53) | <0.001 | ||
| BED (Gy) ≤75 vs. >75 | 0.47 (0.32–0.69) | <0.001 | ||
| Fractions ≤16 vs. >16 | 2.79 (1.89–4.12) | <0.001 | NI | |
| ALC pre-RT (×109/L) ≤1.3 vs. >1.3 | 0.81 (0.54–1.22) | 0.313 | ||
| ALC post-RT (×109/L) ≤0.5 vs. >0.5 | 0.41 (0.26–0.65) | <0.001 | ||
| Lymphocyte nadir (×109/L) ≤0.5 vs. >0.5 | 0.31 (0.19–0.49) | <0.001 | 0.35 (0.19–0.63) | <0.001 |
| GTV (cc) ≤55.0 vs. >55.0 | 3.00 (2.00–4.51) | <0.001 | NI | |
NI = not included.