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Strategies for inhibition of the STAT3 signaling pathway. Several agents targeting various nodes of STAT3 cascade have been developed. Agents that act on nodes 1 and 2 indirectly switch off STAT3 signaling. Compounds at node 3 directly target STAT3 protein or its DNA-binding downmodulating STAT3 activation. p-STAT3: phosphorylated STAT3; p-JAKs: phosphorylated JAKs.
