Table 1.

STAT3-regulated genes.

Tumor-supporting functions of STAT3
Biological functions	Genes		References
Apoptosis	Bcl-2	↑	[44]
	Mcl-1	↑	[24, 30]
	Bcl-xL	↑	[25, 30]
	Survivin	↑	[26, 30]
	Skp2	↑	[27]
	Fas	↓	[28]
Proliferation	c-Myc	↑	[30]
	Pim-1	↑	[30]
	Cyclin-D1	↑	[23]
Angiogenesis	VEGF	↑	[29, 31]
	bFGF	↑	[32]
Immune suppression	IL-10	↑	[33]
	IL-12	↓	[34]
Invasion and metastasis	MMP-1	↑	[30, 36]
	MMP-2	↑	[30, 35]
	MMP-3	↑	[36]
	MMP-9	↑	[36, 37]
	Vimentin	↑	[38]
	TWIST-1	↑	[39]
	p53	↓	[45]
Cancer stem cell	CPT1B	↑	[40]
Self-renewal	ALDH1A1	↑	[41]
Chemoresistance	SOX2	↑	[42]