Table 2.

Anti-STAT3 SLs.

Compound	Cell lines/murine model	STAT3 signaling	Molecular mechanism of STAT3 inhibition		Oxidative stress		Biological effect
Alantolactone	A549, NCI-H1650 [139]	pTyr705STAT3 STAT3 DNA binding	↓ ↓	STAT3 glutathionylation	ROS GSH/GSSG	↑ ↓	Apoptosis Enhanced chemosensitivity
	HepG2 [140]	pTyr705STAT3	↓	STAT3 glutathionylation?	ROS [GSH]	↑ ↓	Apoptosis
	MDA-MB231, MCF-7 [141]	pTyr705STAT3	↓	STAT3 glutathionylation?	ROS [GSH]	↑ ↓	Apoptosis
	BxPC-3, AsPC-1, PANC-1 Athymic BALB/cA [142]	pTyr705STAT3	↓	Binding to STAT3 SH2 domain	No evaluated		Cytotoxicity Inhibited cell migration Enhanced chemosensitivity
Santamarine	HepG2 [143]	pTyr705STAT3 pSrc	↓ ↓	STAT3 glutathionylation?	ROS GSH/GSSG	↑ ↓	Apoptosis
Parthenolide	SGC-7901/DDP [144]	pTyr705STAT3	↓	?	No evaluated		Apoptosis Inhibited cell migration and invasion Enhanced chemosensitivity
	HepG2, HT-29, Lovo, MDA-MB-231, MDA-MB-468, HCT116, H460, NCI-H1299, Colo205, BGC [145]	pTyr705STAT3 pTyr1007/1008 JAK2	↓ ↓	Binding to JAK2	ROS	↑	Cytotoxicity
Costunolide	THP1 [126]	pTyr705STAT3 pTyr1007/1008 JAK2 pTyr1022/1023 JAK1 pTyr1054/1055TyK2	↓ ↓ ↓ ↓	STAT3 glutathionylation?	ROS GSH/GSSG	↑ ↓
1β-hydroxyl-5α-chloro-8-epi-xanthatin	SK-Hep-1, HepG2, SMMC-7721 [146]	pTyr705STAT3 pTyr1007/1008 JAK2	↓ ↓	STAT3 glutathionylation?	ROS GSH/GSSG	↑ ↓	Cytostatic Apoptosis
Bigelovin	HCT 116 HT-29 26-M01 BALB/c nude mice [147, 148]	pTyr705STAT3 STAT3	↓ ↓	STAT3 glutathionylation?	ROS	↑	Inhibited cell migration and invasion Apoptosis
Dehydrocostuslactone	THP1 [126]	pTyr705STAT3 pTyr1007/1008 JAK2 pTyr1022/1023 JAK1 pTyr1054/1055TyK2	↓ ↓ ↓ ↓	STAT3 glutathionylation?	ROS GSH/GSSG	↑ ↓
	MCF-7, MDA-MB-231 BALB/cA-nu [149]	pTyr1007/1008 JAK2 pTyr1022/1023 JAK1 pTyr705STAT3	↓ ↓ ↓	SOCS-1 ↑ SOCS-3 ↑	No evaluated		Cell cycle arrest Apoptosis
	K562 [150]	pTyr1007/1008 JAK2 pTyr705STAT3	↓ ↓	?	ROS	↑	Apoptosis
Cynaropicrin	THP-1 DU-145 [127]	pTyr705STAT3 STAT3 DNA binding	↓ ↓	STAT3 glutathionylation?	ROS [GSH]	↑ ↓	Apoptosis Enhanced chemosensitivity
Deoxyelephantopin	HCT 116, K562, KB, T47D [151]	pTyr705STAT3	↓	STAT3 glutathionylation?	ROS	↑	Cytotoxicity Apoptosis Autophagy
	B16-F10, MeWo A375, A2058, SK-MEL-2 NOD/SCID mice [152]	pTyr705STAT3	↓	STAT3 glutathionylation?	ROS	↑	Cytotoxicity Apoptosis Enhanced chemosensitivity
6-O-angeloylplenolin	NCI-H1975, L78, NCI-292, HCC827, A549, 16HBE, BEAS-2B SCID mice [153]	pTyr705STAT3	↓	Binding to STAT3 SH2 domain	Not evaluated		Apoptosis
	MM.1S, MM.1R, U266 BALB/c nude mice [154]	pTyr705STAT3 pTyr1007/1008 JAK2	↓ ↓	?	Not evaluated		Apoptosis Enhanced chemosensitivity
Antrocin	A549, H1975, H441, PC9, BEAS-2B Mice [155]	pTyr705STAT3 pTyr1007/1008 JAK2 pTyr1022/1023 JAK1 pTyr1054/1055TyK2 STAT3 DNA binding	↓ ↓ ↓ ↓ ↓	?			Apoptosis