Table 1.
Characteristics of patients with MM
| Sample | Sex | Age, y | MM type | M-protein | PCBM, % | MM-PC cytogenetic alterations (FISH) | CRAB | ISS | FLC, mg/L |
|---|---|---|---|---|---|---|---|---|---|
| MM_1 | M | 67 | IgA κ | 1754 mg/dL | 30 | Normal IGH Tx, and P53 | − | 1 | Normal |
| MM_2 | M | 82 | IgA κ | 2234 mg/dL | 23 | Normal IGH Tx; del P53: 40% | − | 2 | Normal |
| MM_4 | M | 66 | IgG λ | 5818 mg/dL | 48.8 | t(4;14): 61%; normal P53 | − | 3 | 62.6 |
| MM_5 | M | 81 | IgG κ | 3547 mg/dL | 22 | Normal IGH Tx, and P53 | − | 2 | 25 |
| MM_6 | M | 63 | IgG κ | 2270 mg/dL | 50 | Normal IGH Tx, and P53 | Renal | 1 | 165 |
| MM_7 | M | 43 | BJ κ | 1.6 g/d | 15.2 | Normal IGH Tx; del P53: 6% | Plasmacytoma | 1 | 1 222 |
| MM_8 | F | 69 | IgA λ | 3991 mg/dL | 42 | Normal IGH Tx, and P53 | HyperCa, anemia, bone | 2 | 49.6 |
| MM_9 | M | 82 | IgG λ | 7670 mg/dL | 22 | Normal IGH Tx, and P53 | Renal, anemia, bone | 3 | 2 720 |
| MM_10 | F | 77 | BJ λ | 6 g/d | 50 | Normal IGH Tx, and P53 | Bone, plasmacytoma | 1 | 2 500 |
| MM_11 | F | 60 | IgG κ | 6549 mg/dL | 60 | Normal IGH Tx, and P53 | HyperCa, anemia, bone | 2 | 36.3 |
| MM_12 | F | 74 | IgA λ | 2790 mg/dL | 19.2 | t(4;14): 22%; normal P53 | Renal, anemia | 2 | 567 |
| MM_13 | M | 49 | BJ κ | 1.4 g/d | 36 | t(4;14): 38%; normal P53 | Renal, bone | 3 | 16 500 |
| MM_14 | M | 56 | IgA λ | 3484 mg/dL | 14.4 | Normal IGH Tx; del P53: 3% | Anemia, bone | 1 | 128 |
| MM_15 | F | 70 | BJ λ | 9.0 g/d | 70 | Normal IGH Tx, and P53 | Renal, anemia, bone | 3 | 3 100 |
| MM_16 | M | 69 | BJ λ | 7 g/d | 19 | Normal IGH Tx, and P53 | Plasmacytoma | 1 | 402 |
| MM_17 | M | 79 | IgG κ | 3603 mg/dL | 50 | Normal IGH Tx, and P53 | Anemia, bone | 2 | 430 |
| MM_18 | M | 71 | BJ λ | 15 g/d | 18.8 | Normal IGH Tx, and P53 | Bone | 3 | 4 110 |
| MM_19 | F | 62 | IgG λ + BJ λ | 562 mg/dL | 36.8 | Normal IGH Tx, and P53 | Anemia | 1 | 550 |
| MM_20 | F | 74 | IgG κ | 3471 mg/dL | 25 | Normal IGH Tx, and P53 | Bone | 1 | 16.8 |
| MM_21 | F | 68 | IgG λ | 7339 mg/dL | 41.6 | t(4;14): 79%; normal P53 | HyperCa, anemia, bone | 3 | 298 |
| MM_22 | M | 77 | IgG κ | 5669 mg/dL | 54.8 | Normal IGH Tx, and P53 | HyperCa, renal anemia, bone | 3 | 4 050 |
BJ, Bence-Jones; CRAB, hypercalcemia, renal insufficiency, anemia, and bone lesions; F, female; FISH, fluorescence in situ hybridization; FLC, free light chain; IgG, immunoglobulin G; HyperCa, hypercalcemia; ISS, International Staging System; M, male; PCBM, myelomatous plasma cell infiltration in bone marrow; Tx, chromosomal translocation.