Table 3.
Multivariable regression analysis showing independent predictors of HDL functionality in adolescents with Type 1 diabetes
| NO bioavailability (% change from buffer-treated cells) |
SO production (nmol O2 per 250 000 cells) |
PON-1 activity (µMol P-nitrophenol/L/serum/min) |
||||
|---|---|---|---|---|---|---|
| Beta (95% CI) | P-value | Beta (95% CI) | P-value | Beta (95% CI) | P-value | |
| ACR group (H/L) | −9.3 (−13.7 to −4.8) | <0.001 | 1.59 (−0.38 to 3.56) | 0.112 | −15 (−234 to 204) | 0.892 |
| Inflammation (H/L) | −1.4 (−5.7 to 3.0) | 0.527 | 2.35 (0.42 to 4.27) | 0.018 | 70 (−148 to 287) | 0.523 |
| eGFR (mL/min/1.73 m2) | 0.1 (0.0 to 0.2) | 0.093 | −0.02 (−0.07 to 0.03) | 0.446 | 0 (−6 to 6) | 0.955 |
| HbA1c (%) | 0.3 (−1.7 to 2.3) | 0.763 | −0.19 (−1.06 to 0.69) | 0.672 | 2 (−93 to 97) | 0.966 |
| Age (years) | −0.1 (−1.2 to 1.4) | 0.887 | −0.71 (−0.33 to 0.41) | 0.604 | −39 (−104 to 26) | 0.231 |
| Disease duration (years) | −0.2 (−0.8 to 0.4) | 0.520 | 0.18 (−0.07 to 0.43) | 0.151 | 13 (−16 to 42) | 0.372 |
| Sex (M/F) | 0.4 (−.4.7 to 4.0) | 0.861 | −0.35 (−2.28 to 1.58) | 0.717 | 79 (−141 to 300) | 0.475 |
| BMI (z-score) | −0.4 (−2.8 to 2.1) | 0.765 | −0.85 (−1.93 to 0.23) | 0.119 | 23 (−102 to 148) | 0.712 |
Bold denotes significant difference (P<0.05). ACR, albumin:creatinine ratio; BMI, body mass index; eGFR, estimated glomerular filtration rate; HbA1c, glycated haemoglobin; Inflammation, inflammatory risk score.