Take home figure.

In 75-year-old primary prevention patients previously adherent to statin therapy for at least 2 years, discontinuation of statins was associated with an increased risk of admission for a cardiovascular event. Cumulative incidence functions were adjusted for confounding due to baseline and time-varying covariates using inverse probability of treatment and censoring weighting. 95% confidence intervals are indicated by hatched curves. Under the assumptions required by this method (see Supplementary material online, Table S2), the cumulative incidence estimated for statin discontinuation represents the experience of the entire study population had all individuals discontinued statins right from the beginning of follow-up. The cumulative incidence estimated for statin continuation represents the experience of the entire study population had no individuals discontinued statins during follow-up.