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. 2019 Nov 7;10:2572. doi: 10.3389/fmicb.2019.02572

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Copyright © 2019 Creighbaum, Ticak, Shinde, Wang and Ferguson.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Proposed model of GB-dependent CoM methylation. Proteins are represented by colored circles/ovals and locations of genes that encode for them are also represented. The first methyltransferase, MtgB (blue), is a Pyl-lacking member of the COG5598 superfamily. MtgB catalyzes transfer of a methyl group from GB to the cognate corrinoid-binding protein, MtgC (red). The second methyltransferase, MtaA (green), catalyzes methyl transfer from Me-MtgC to CoM. The corrinoid reductive activation enzyme, RamM (purple), reduces the bound corrinoid of MtgC, when required. DMG is dimethylglycine.