Table 4.
Patient conditions and sample sources among discordant negative DFME and positive PCR resultsa
| Patient no. n = 27 (%) | |
|---|---|
| Primary patient medical condition | |
| Hematologic malignancy and other hematologic disordersb | 9 (33%) |
| Chronic lung disease with immunosuppressive drug therapyc | 5 (19%) |
| Solid organ malignancyd | 4 (15%) |
| Active connective tissue diseasee | 4 (15%) |
| Kidney/pancreas transplantation | 3 (11%) |
| HIV infection/AIDS | 2 (7%) |
| Specimen source | |
| BAL | 18 (67%) |
| Induced sputum | 6 (22%) |
| Tracheal secretions | 2 (7%) |
| Lung tissue/biopsy | 1 (4%) |
Patients and samples from Mayo Clinic Rochester, MN. Note 2 of the 29 total patient samples with discordant test results from Table 3 are omitted as they were not patients at the Mayo Clinic and their records could not be reviewed.
Hematologic malignancies and other hematologic disorders: chronic lymphocytic leukemia (n = 3), multiple myeloma (n = 2), non-Hodgkin lymphoma (n = 1), Hodgkin disease (n = 1), acute myelogenous leukemia (n = 1), and aplastic anemia (n = 1).
Chronic lung disease with immunosuppressive therapy: interstitial lung disease (n = 2), bronchiolitis obliterans (n = 1), steroid-dependent asthma (n = 1) and idiopathic constrictive bronchiolitis (n = 1).
Solid organ malignancies: invasive breast carcinoma (n = 2), glioblastoma multiforme (n = 1), and recurrent pontine glioma (n = 1).
Active connective tissue diseases: Goodpasture disease (n = 2), rheumatoid arthritis (n = 1), and polymyalgia rheumatica (n = 1).