Table 5.
Analysis of discordant DFME and PCR results by specimen type
| Clinical likelihood for PCP in patients with discordant P. jirovecii test results |
Sputum (n = 6) | Tracheal secretions (n = 2) | Lung tissue (n = 1) | BAL (n = 18) | Total (n = 27) |
|---|---|---|---|---|---|
| Definite or probableb | 4 (67%) | 2 (100%) | 1 (100%) | 14 (78%) | 21 (78%) |
| Possiblec | 1 (17%) | 0 (0%) | 0 (0%) | 3 (17%) | 4 (15%) |
| Unlikelyd | 1 (17%) | 0 (0%) | 0 (0%) | 1 (6%) | 2 (7%) |
| 100% | 100% | 100% | 100% | 100% |
a
Discordant samples defined as those with initial negative DFME and subsequent positive PCR.
b
Definite or probable PCP—P. jirovecii determined to be the primary cause of pulmonary disease based on the positive PCR test result with corresponding clinical and radiologic findings, the absence of an alternative diagnosis, and the decision to treat for PCP.
c
Possible PCP—not able to clinically confirm or exclude P. jirovecii contribution to pulmonary disease, but patients were treated for PCP.
d
Unlikely PCP—P. jirovecii determined not to cause the pulmonary syndrome. Patients did not receive treatment for PCP and remained stable or improved.