Figure 4.

(A) Depiction of DMRT1 demonstrating the p.R80S mutation identified, with amino acid conservancy shown below. The position of p.R80 is indicated by a red arrowhead. (B) Schematic representation of the DMRT1–DNA complex (PDB ID 4YJ0). The DMRT1 protein is shown in white and the R80 residues are depicted as spheres; zinc atoms are shown in magenta. (C) Snapshot of the R80 or S80 vicinity (upper) and electrostatic potential of surface of the respective DMRT1-DNA complexes (lower). (D) Cα-root-mean-squared (RMSD) deviation and distances between Arg or Ser 80 and the phosphate backbone of the DNA along the molecular dynamics simulation.