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. 2019 Oct 10;3(12):2341–2360. doi: 10.1210/js.2019-00306

Figure 5.

Figure 5.

(A) Depiction of NR5A1 (SF-1) demonstrating the mutations identified, with amino acid conservancy shown below. The positions of variants are indicated by red arrowheads. (B) Transient transfection assays showing activation of a Cyp11a1 promoter by WT SF-1 and impaired transcriptional activity by the p.G22D and p.L420P mutants. Results are shown as a percentage of WT SF-1 activity (relative light units). Data are shown as mean ±SEM of three experiments performed in triplicate. Zn, Zinc finger.