Table 5.
Pathways relevant to 14 differential metabolites.
| Pathway | Metabolites | Total | Impact | Hits | p value |
|---|---|---|---|---|---|
| Alanine, aspartate, and glutamate metabolism | L-Glutamine, fumaric acid, succinic acid | 24 | 0.1396 | 3 | 0.0003 |
| Butanoate metabolism | (R)-3-Hydroxybutyric acid, succinic acid, fumaric acid | 40 | 0.2327 | 3 | 0.0014 |
| Citrate cycle (TCA cycle) | Succinic acid, fumaric acid | 20 | 0.1163 | 2 | 0.0056 |
| Fructose and mannose metabolism | Sorbitol, mannitol | 48 | 0.2792 | 2 | 0.0304 |
| Lysine degradation | Aminoadipic acid, glycine | 47 | 0.2734 | 2 | 0.0293 |
| Nitrogen metabolism | L-Glutamine | 39 | 0.2268 | 2 | 0.0206 |
| Phenylalanine metabolism | Phenylpyruvic acid, succinic acid, fumaric acid | 45 | 0.2617 | 3 | 0.0019 |
| Synthesis and degradation of ketone bodies | (R)-3-Hydroxybutyric acid | 6 | 0.0349 | 1 | 0.0344 |
| Tyrosine metabolism | Homogentisic acid, fumaric acid, succinic acid | 76 | 0.442 | 3 | 0.0086 |
| Valine, leucine, and isoleucine biosynthesis | Alpha-ketoisovaleric acid, 4-Methyl-2-oxopentanoate | 27 | 0.157 | 2 | 0.0102 |
| Valine, leucine, and isoleucine degradation | Alpha-ketoisovaleric acid, 4-Methyl-2-oxopentanoate | 40 | 0.2327 | 2 | 0.0216 |
TCA, tricarboxylic acid.