Table 2: Patient Demographics, Epilepsy and Sleep Variables.
The Table shows data for the overall cohort (n=49) and the subset of patients with analyzable oximetry data (n=43), comparing those with probable OSA having an ODI ≥ 5/hour, and those without probable OSA having ODI < 5/hour.
| All Patients (n=49) | Probable OSA (ODI ≥ 5, n= 15)a | No Probable OSA (ODI < 5, n = 28)b | p-value (a vs b) | |
|---|---|---|---|---|
| Age (years) | 37.2 ± 12.1 | 42.5 ± 13.5 | 33.6 ± 10.9 | 0.03 |
| Sex (M/F) | 22 / 27 | 8/7 | 11/17 | NS |
| Mean BMI (kg/m2) | 26.3 ± 6.1 | 29.5 ± 5.7 | 24.3 ± 5.2 | 0.005 |
| BMI>/= 30 kg/m2 | 13 (33.3%) | 8 (53.3%) | 7 (43.7%) | 0.002 |
| Mean rSUDEP-7 | 2.9 ± 1.4 | 3.4 ± 1.7 | 2.5 ± 1.1 | NS |
| Mean SUDEP-7 | 3.3 ± 1.7 | 3.7 ± 2.0 | 3.0 ± 1.5 | NS |
| Focal epilepsy n (%) | 36 (73%) | 14 (93%) | 17 (60%) | 0.01 |
| Primary Generalized epilepsy n (%) | 11 (22%) | 1 (7%) | 9 (32) | 0.04 |
| Unspecified-type epilepsy n (%) | 2 (4%) | 0 (0%) | 0 (0%) | NS |
| Nocturnal seizures n (%) | 18 (37%) | 4 (27%) | 13 (46%) | NS |
| Refractory epilepsy n (%) | 32 (65%) | 9 (60%) | 18 64%) | NS |
| Duration of epilepsy (years) | 16.7 ± 14.5 | 27.5 ± 15.7 | 10.9 ± 8.5 | 0.0005 |
| Duration of epilepsy >15 years n (%) | 15 (31%) | 10 (67%) | 5 (18%) | 0.0002 |
| Seizure frequency (days per month) | 10.4 ± 14.8 | 10.7 ± 12.4 | 10.8 ± 17.2 | NS |
| Anti-epileptic drugs | 2.2 ± 0.9 | 2.1 ± 1.0 | 2.2 ± 0.8 | NS |
| Anti-epileptic drug load | 2.6 ± 1.6 | 2.3 ± 1.9 | 2.6 ± 1.5 | NS |
| OSA Dx by Any Measure n (%) | 19 (39%) | NA | NA | |
| OSA Dx by Oximetry* | 15 (35%) | NA | NA | |
| ODI* | 4.7 ± 5.8 | 11.3 ± 5.1 | 1.1 ± 1.0 | <0.0001 |
| OSA Dx by SA-SDQ n (%) | 10 (20%) | 6 (40%) | 2 (7%) | 0.005 |
| SA-SDQ Score (range) | 22.2 ± 8.2 (13–49) | 27.6 ± 8.8 (17–49) | 19.0 ± 6.2 (13–37) | <0.0001 |
| OSA Dx by STOP-BAG | 6 (12%) | 8 (40%) | 2 (7%) | 0.009 |
| STOP-BAG Score (range) | 1.2 ± 1.1 (0–5) | 1.9 ± 0.9 (1–4) | 0.8 ± 0.9 (0–4) | <0.0001 |
| ESS | 7.6 ± 3.5 | 7.9 ±3.6 | 7.4 ± 3.6 | NS |
| Psychiatric Hx n (%) | 16 (33%) | 5 (33%) | 9 (32%) | NS |
| Hypertension/Hyperlipidemia n, (%) | 6 (12%) | 1 (7%) | 5 (18%) | NS |
| Migraine Hx n (%) | 11 (22%) | 4 (27%) | 6 (21%) | NS |
| TBI Hx n (%) | 7 (14%) | 1 (7%) | 4 (14%) | NS |
| Structural brain lesion n (%) | 6 (12%) | 1 (7%) | 3 (11%) | NS |
*
43 subjects had analyzable oximetry data
rSUDEP-7=Revised Sudden unexpected death in epilepsy score; BMI=body mass index; OSA=obstructive sleep apnea; Dx=diagnosis; Hx=History; TBI=Traumatic Brain Injury; ESS=Epworth sleepiness scale; ODI=oxygen desaturation index, SA-SDQ=sleep apnea-sleep disorders questionnaire