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. 2019 Nov 7;10:727. doi: 10.3389/fendo.2019.00727

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Copyright © 2019 Bender, Campbell, Aytoda, Mathiesen and Duffy.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Follicle rupture and oocyte release are compromised after intrafollicular injection with an antibody against THBS1. Ovarian surface at the time of ovary removal after intrafollicular injection of control IgG (A) or THBS1 antibody (B–D). Oocytes were located within a THBS1 antibody-injected follicle (E) and on the surface of a THBS1 antibody-injected follicle (F). Rupture site after intrafollicular injection of control IgG (G). Rupture sites in follicles injected with the THBS1 antibody were either small (H) or absent (I). Tissues shown in (E–I) were stained with hematoxylin and eosin. Oocytes (E,F) shown at approximately maximal diameter. Images in (G–I) are at the same magnification; bar in (I) = 0.5 mm. (J) Rupture site area after intrafollicular injection with control IgG (IgG) or THBS1 antibody. Groups are different by two-tailed unpaired t-test as indicated by *p < 0.05. Data are expressed as mean + SEM, n = 4/group.