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. 2019 Nov 7;10:1092. doi: 10.3389/fgene.2019.01092

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Copyright © 2019 Potter, Chial, Caneus, Elos, Elder, Borysov and Granic

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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How mosaic aneuploidy may lead to neuronal loss in neurodegenerative and neurodevelopmental disorders. Shown is a schematic of how mosaic aneuploidy may occur in neurons leading to apoptosis and cognitive deficits in neurodevelopmental and aging-associated neurodegenerative disorders. Seckel syndrome (SS), ataxia telangiectasia (AT), Niemann–Pick type C disease (NPC), Nijmegen breakage syndrome (NBS), Fanconi anemia (FA), xeroderma pigmentosum (XP), Down syndrome (DS), Alzheimer’s disease (AD), frontotemporal lobar degeneration (FTLD), Lewy body disease (LBD), and Huntington’s disease (HD).