. 2019 Aug 16;10(34):7835–7851. doi: 10.1039/c9sc03368h

Table 1. Characteristics of currently used click chemistry reactions ^a .

Name	Representative reaction	k (M^–1 s^–1)	Pros/cons
CuAAC		∼10–100 (with 20 μM Cu(i))8	- Both small structures
			- Cheap price
			- Toxic copper catalyst
			- High second order reaction rate constant
SPAAC		∼1–60 (M^–1 s^–1)9	- One small and one large structure
			- Moderate second order reaction rate constant
			- No catalyst
iEDDA		∼1–10⁶ (M^–1 s^–1)10	- Two large structures
			- Very high second order reaction rate constant
			- No catalyst

^aCuAAC: copper-catalyzed [3 + 2] azide–alkyne cycloaddition; SPAAC: strain-promoted azide–alkyne cycloaddition; iEDDA: inverse-electron-demand Diels–Alder reaction.

Table 1. Characteristics of currently used click chemistry reactions a .

Table 1. Characteristics of currently used click chemistry reactions ^a .