TABLE 4.

Effect of allopurinol on biomarkers

Change in measured parameter	Placebo	Allopurinol	P value
Uric acid (umol/l)	−1.33 ± 37.04	−189.56 ± 91.95	<0.001
HsCRP (mg/l)	−0.55 ± 2.10	0.22 ± 1.71	0.122
TBARS (μmol/l)	−0.34 ± 0.83	0.26 ± 0.85	0.007
NTProBNP (pg/ml)	109.08 ± 491.03	−109.03 ± 612.84	0.131
PICP (ng/l)	−0.18 ± 0.60	−0.05 ± 0.43	0.322
Soluble ST2 (ng/ml)	−1.02 ± 3.39	−0.61 ± 8.63	0.573

HsCRP, high-sensitivity C-reactive protein; NTproBNP, N-terminal pro B natriuretic peptide; PICP, N-terminal pro b-type natriuretic peptide; TBARs, thiobarbituric acid reactive substances.