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. Author manuscript; available in PMC: 2019 Nov 14.
Published in final edited form as: ACS Chem Biol. 2018 Oct 30;13(11):3043–3048. doi: 10.1021/acschembio.8b00429

Figure 4: Increasing relative amounts of CMeT results in hypermethylation of pentaketide intermediates.

Figure 4:

A) PksCT SAT-KS-MAT and ACP were incubated with increasing concentrations of PksCT CMeT. Traces are vertically stacked and the peak for 1 is truncated for clarity. B) Control of C-methylation programming is proposed to rely on the rates of extension and methylation for each acyl-ACP intermediate produced.