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. Author manuscript; available in PMC: 2020 Jan 1.
Published in final edited form as: Magn Reson Imaging. 2018 Sep 10;55:7–25. doi: 10.1016/j.mri.2018.09.004

Table 1.

Diffusion MRI tractography algorithms.

Algorithm # Pre-Processing? Reconstruction Technique Software Tractography Method Algorithm Seed Miscellaneous
1 None DTI Diffusion Toolkit + Trackvis Deterministic FACT + Spline filtering Seed (as ROI) Diffusion Toolkit default parameters
2 Seed600um (as ROI)
3 Sphere ROI (r=10v) centered on Seed
4 None Qball Diffusion Toolkit + Trackvis Deterministic FACT + Spline filtering Seed (as ROI) Diffusion Toolkit default parameters
5 Seed600um (as ROI)
6 Sphere ROI (r=10v) centered on Seed
7 None Ball & Sticks (bedpostx) FSL Probablistic Probtrackx Seed (as seed) FSL Default Parameters: No FA Threshold
8 Seed600um (as seed)
9 None DTI DSI Studio Deterministic DSI Studio default tracking Seed (as ROI) 2000 tracks generated
10 Seed (as seed)
11 Seed600 (as ROI)
12 Seed600 (as seed)
13 Sphere ROI (r=10v) centered on seed
14 Sphere seed (r=10v) centered on seed
15 None Qball DSI Studio Deterministic DSI Studio default tracking Seed (as ROI) - SH order = 4
- No ODF Sharpening
- 2000 tracks generated
16 Seed (as seed)
17 Seed600 (as ROI)
18 Seed600 (as seed)
19 Sphere ROI (r=10v) centered on seed
20 Sphere seed (r=10v) centered on seed
21 Response function estimated from highest FA voxels CSD MRTrix Probablistic* iFOD2 Seed (as seed) MRTrix3 Default Parameters
- 5000 Tracks generated
22 Seed600um (as seed)
23 Seed (as ROI)
24 Seed600 (as ROI)
25 Response function estimated from iterative method CSD MRTrix Probablistic* iFOD2 Seed (as seed) MRTrix3 Default Parameters
- 5000 Tracks generated
26 Seed600um (as seed)
27 Seed (as ROI)
28 Seed600 (as ROI)
29 None DTI MRTrix Deterministic TensorDet Seed (as seed) MRTrix3 Default Parameters
- 5000 Tracks generated
30 Seed600um (as seed)
31 Seed (as ROI)
32 Seed600 (as ROI)
33 None DTI MRTrix Probabalistic TensorProb Seed (as seed) MRTrix3 Default Parameters
- 5000 Tracks generated
34 Seed600um (as seed)
35 Seed (as ROI)
36 Seed600 (as ROI)
37 Response function estimated from highest FA voxels CSD MRTrix Probablistic* SIFT + iFOD2 Seed (as ROI) 10 million streamlines SIFTed to 1 million
38 Seed600um (as ROI)
39 Response function estimated from iterative method CSD MRTrix Probablistic* SIFT + iFOD2 Seed (as ROI) 10 million streamlines SIFTed to 1 million
40 Seed600 (as ROI)
*

We note that the MRTrix iFOD2 algorithm uses samples drawn from a fiber orientation distribution to build the streamlines, and aims to reflect the anatomical distribution of fibers rather than statistical uncertainty. Thus, these are not “strictly” probabilistic, but share many similarities and are often described as probabilistic.