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. 2019 Nov 14;14(11):e0225239. doi: 10.1371/journal.pone.0225239

Table 1. Drug lists for the detection of potential DDIs.

Drug class Drug groups Drug lists
Cardiac drugs Beta blockers 1. Atenolol
2. Bisoprolol
3. Carvedilol
4. Esmolol
5. Metoprolol
6. Nebivolol
7. Propranolol
Antianginal agents 8. Ranolazine
9. Trimetazidine
Vasodilating agents Phosphodiesterase inhibitors 10. Dipyridamole
Arteriolar dilators 11. Hydralazine
12. Minoxidil
Prostacyclin analogues 13. Iloprost
14. Beraprost
Nitrates 15. Isosorbide dinitrate
16. Isosorbide mononitrate
17. Nitroglycerin
Phosphodiesterase-5 inhibitors 18. Sildenafil
Peripheral vasodilators and related agents Peripheral vasodilator agents 19. Nicergoline
Xanthine derivatives 20. Pentoxifylline
Antiplatelets Cyclooxygenase inhibitors 21. Acetylsalicylic acid
Phospholipase-3 inhibitors 22. Cilostazol
23. Omega-3-acid ethyl ester
Antilipemic agents Chelating agents 24. Cholestyramine
Fibrates 25. Fenofibrate
26. Gemfibrozil
HMG-CoA reductase inhibitors 27. Atorvastatin
28. Pitavastatin
29. Pravastatin
30. Rosuvastatin
31. Simvastatin
Nicotinic acid 32. Nicotinic acid
Selective cholesterol absorption inhibitors 33. Ezetimibe
PCSK9 inhibitors 34. Evolocumab
Antihypertensive drugs Angiotensin converting enzyme inhibitors 35. Captopril
36. Enalapril
37. Imidapril
38. Perindopril
39. Quinapril
40. Ramipril
Angiotensin receptor blockers 41. Azilsartan
42. Candesartan
43. Irbesartan
44. Losartan
45. Olmesartan
46. Telmisartan
47. Valsartan
Neprilysin inhibitors 48. Sacubitril valsartan sodium salt complex
Thiazide and related diuretics 49. Hydrochlorothiazide
50. Indapamide
51. Chlorthalodine
Alpha-2 adrenergic receptors 52. Methyldopa
53. Clonidine
Alpha adrenergic antagonists 54. Doxazosin
55. Prazosin
Calcium channel blockers 56. Amlodipine
57. Diltiazem
58. Felodipine
59. Lercanidipine
60. Manidipine
61. Nifedipine
62. Nimodipine
63. Verapamil
Direct renin inhibitors 64. Aliskiren
Endothelin-1 receptor antagonists 65. Bosentan
66. Macitentan
Diuretics Diuretics loop diuretics 67. Furosemide
Carbonic anhydrase inhibitors 68. Acetazolamide
Osmotic diuretics 69. Mannitol
70. Glycerin
Potassium-sparing diuretics 71. Amiloride
72. Spironolactone
Antidiabetic drugs Alpha-glucosidase inhibitors 73. Acarbose
Biguanides 74. Metformin
Dipeptidyl peptidase-4 inhibitors 75. Linagliptin
Glucagon-like peptide-1 receptor agonists 76. Liraglutide
77. Dulaglutide
Meglitinide analogs 78. Repaglinide
Sodium glucose co-transporter type 2 inhibitors 79. Dapagliflozin
80. Empagliflozin
Sulfonylureas 81. Glimepiride
82. Glipizide
Thiazolidinediones 83. Pioglitazone
Insulins 84. Insulin