Table 5. The significant difference of the severity in potential DDIs analyzed by Micromedex and Drugs.com.

Micromedex	Drugs.com	DDIs paired list with different severity
Contraindication	None	1. Aliskiren—Sacubitril
Major	Minor	1. Aspirin—Furosemide 2. Aspirin—Spironolactone 3. Nifedipine—Pioglitazone
Major	None	1. Acarbose—Aspirin 2. Acarbose—Glipizide 3. Acarbose—Pioglitazone 4. Aspirin—Amiloride 5. Aspirin—Chlorthalidone 6. Aspirin—Hydrochlorothiazide 7. Aspirin—Indapamide 8. Aspirin—Metformin 9. Clonidine—Metoprolol succinate 10. Clonidine—Metoprolol tartrate 11. Glimepiride—Pioglitazone 12. Glipizide—Pioglitazone 13. Metformin—Pioglitazone 14. Metoprolol succinate—Diltiazem 15. Metoprolol succinate—Verapamil 16. Metoprolol tartrate—Diltiazem 17. Metoprolol tartrate—Verapamil
None	Major	1. Amiloride—Azilsartan 2. Amiloride—Olmesartan 3. Amiloride—Spironolactone 4. Bosentan—Ranolazine 5. Clonidine—Metoprolol 6. Diltiazem—Metoprolol 7. Spironolactone—Azilsartan 8. Spironolactone—Olmesartan 9. Verapamil—Metoprolol