Skip to main content
. 2019 Nov 14;14(11):e0223955. doi: 10.1371/journal.pone.0223955

Table 4. Biological pathways with over-represented genes of 2340 significantly down-regulated genes using a web tool (DAVID Bioinformatics Resources 6.8) during the first 18 hours of infection.

Pathway # Pathway name Hours PI Count FDR
GO:0016567 protein ubiquitination 15 39 0.04
GO:0070125 mitochondrial translational elongation 15, 18 17 0.01
R-HSA-5368286 Mitochondrial translation initiation 15, 18 16 0.01
R-HSA-5389840 Mitochondrial translation elongation 15, 18 17 0.00
R-HSA-5419276 Mitochondrial translation termination 15, 18 16 0.01
GO:0002479 antigen processing and presentation of via MHC class I, TAP-dependent 18 21 0.03
GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c 18 10 0.02
GO:0006886 intracellular protein transport 18 57 0.00
GO:0006888 ER to Golgi vesicle-mediated transport 18 39 0.02
GO:0006914 autophagy 18 41 0.00
GO:0015031 protein transport 18 89 0.00
GO:0016236 macroautophagy 18 25 0.01
GO:0019886 antigen processing and presentation of via MHC class II 18 27 0.02
GO:0030433 ER-associated ubiquitin-dependent protein catabolic process 18 21 0.01
GO:0033572 transferrin transport 18 17 0.00
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process 18 45 0.05
GO:0045454 cell redox homeostasis 18 24 0.02
GO:0070126 mitochondrial translational termination 18 34 0.00
GO:0090383 phagosome acidification 18 13 0.03
hsa00190 Oxidative phosphorylation 18 46 0.00
hsa01100 Metabolic pathways 18 220 0.00
hsa04141 Protein processing in endoplasmic reticulum 18 52 0.00
hsa04142 Lysosome 18 45 0.00
hsa04145 Phagosome 18 51 0.00
hsa04932 Non-alcoholic fatty liver disease (NAFLD) 18 48 0.00
hsa05010 Alzheimer’s disease 18 51 0.00
hsa05012 Parkinson’s disease 18 38 0.05
R-HSA-1222556 ROS, RNS production in phagocytes 18 17 0.00
R-HSA-1236974 ER-Phagosome pathway 18 27 0.01
R-HSA-2132295 MHC class II antigen presentation 18 36 0.00
R-HSA-5628897 TP53 Regulates Metabolic Genes 18 28 0.00
R-HSA-5678895 Defective CFTR causes cystic fibrosis 18 21 0.03
R-HSA-611105 Respiratory electron transport 18 30 0.00
R-HSA-917977 Transferrin endocytosis and recycling 18 14 0.02
GO:0006886 intracellular protein transport pooled 62 0.00
GO:0042147 retrograde transport, endosome to Golgi pooled 23 0.03
R-HSA-1268020 Mitochondrial protein import pooled 20 0.05
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation pooled 68 0.02