| Key Parameters |
| Pediatric HIV treatment coverage |
Percentage of eligible children (0–14 ages) in need of ART reached |
National-level coverage rates are generally publicly reported. |
Data reported by Ministries of Health, UNAIDS, United Nations Children's Fund (UNICEF), WHO |
| Routine viral load testing (different rates for first- and second-line treatment) |
Percentage of ART patients who undergo viral load testing (assumes 1 routine test per patient per year) |
Limited data exists regarding routine viral load testing among pediatric patients. In the absence of appropriate national-level data, values should reflect clinical study data, available testing data (adult populations), and qualitative data on testing infrastructure and routine testing practices in resource-limited settings. |
Clinical study data, qualitative data from peer-reviewed articles, UNAIDS data (adults only) |
| Viral load non-suppression rate (different rates for first- and second-line treatment) |
Percentage of patients receiving viral load tests who are not virologically suppressed |
Limited data exists regarding pediatric viral load suppression rates. In the absence of appropriate national-level data, values should reflect relevant clinical study data, available viral load suppression rate data (adult populations), and qualitative data on factors influencing suppression rates and trends. |
Clinical study data, qualitative data from peer-reviewed articles, UNAIDS data (adults only) |
| Confirmed treatment failure (different rates for first- and second-line treatment) |
Percentage of patients whose treatment failure is confirmed by a confirmatory viral load test (or, where available and appropriate, a resistance test) prior to switching to second-line |
Limited data exists regarding pediatric HIV treatment failure. In the absence of appropriate national-level data, values should reflect a survey of clinical studies and observations from practicing clinicians. Recent WHO data revealed a broad range of estimated treatment failure rates (from over 30% to 0.5%). |
Clinical study data, qualitative data from peer-reviewed articles, WHO data
|
| Patient loss (different rates for first- and second-line treatment) |
Percentage of patients lost following viral load testing and not linked to additional care (drivers include lack of access, loss to follow up, and mortality) |
At various stages over the course of treatment, patients will be lost due to lack of access (to treatment, services, and/or care), loss to follow up, and mortality. In the absence of appropriate national-level data, values should reflect clinical study data. A review of recent studies suggests that adherence is a larger problem for pediatric patients than for adult patients and that there are greater barriers to access for pediatric HIV services and care as compared to adult services. |
Clinical study data, qualitative data from peer-reviewed articles |
| Foundational Parameters |
| Mortality |
Annual number of pediatric HIV patient deaths expressed as a percentage of the total pediatric HIV patient pool |
National-level AIDS-related mortality rates for the pediatric HIV+ population are generally publicly reported. |
UNAIDS data (children) |
| New cases |
Decrease in number of new cases of HIV infections among children (0–14 years) expressed as a percentage change |
National-level data on new cases of pediatric HIV are generally publicly reported. |
UNAIDS data (children) |
| Rate of aging out |
Percentage of children who age out of the 0–14 age cohort (on an annual basis) |
In the absence of national-level data for the pediatric HIV+ population, demographic data for the general population within the 0–14 age cohort can be used as a proxy. |
UN World Population Prospects |
