Table 2. Multivariate logistic regression results for small vessel disease before SMR adjustment.

Variables	All cerebral SVD		WMH		CMB		Silent lacunar infarct
	Odds ratio (95% CI)	p-value	Odds ratio (95% CI)	p-value	Odds ratio (95% CI)	p-value	Odds ratio (95% CI)	p-value
NAION	4.81 (2.68–8.66)	<0.001	4.50 (2.53–8.01)	<0.001	2.23 (1.05–5.17)	0.04	2.22 (1.07–4.61)	0.033
Age (yr)	1.07 (1.06–1.08)	<0.001	1.08 (1.07–1.09)	<0.001	1.03 (1.02–1.05)	<0.001	1.07 (1.05–1.09)	<0.001
Sex (men)	0.80 (0.66–0.96)	0.016	0.73 (0.60–0.88)	0.001	1.26 (0.918–1.74)	0.168	1.07 (0.82–1.40)	0.623
Hypertension	1.89 (1.58–2.25)	<0.001	1.91 (1.59–2.29)	<0.001	1.78 (1.31–2.42)	<0.001	2.15 (1.65–2.79)	<0.001
Diabetes	1.24 (0.99–1.56)	0.062	1.25 (0.99–1.58)	0.057	0.95 (0.64–1.40)	0.794	1.38 (1.02–1.87)	0.039
Dyslipidemia	0.94 (0.73–1.21)	0.625	0.99 (0.77–1.29)	0.990	1.01 (0.65–1.56)	0.967	1.05 (0.72–1.53)	0.789
Smoking	0.96 (0.78–1.18)	0.680	0.90 (0.73–1.12)	0.357	1.18 (0.80–1.73)	0.410	1.07 (0.77–1.49)	0.687

SMR: standardized mortality ratio; SVD: small vessel disease; WMH: white matter hyperintensities; CMB: cerebral microbleeds; CI: confidence interval; NAION: nonarteritic anterior ischemic optic neuropathy