Fig 3. Gene expression differences between DU145 and LNCaP.

Differentially expressed genes between radioresistant and radiosensitive cell lines were determined for DU145 and LNCaP. Identified under- (top panels) and overexpressed genes (bottom panels) in the radioresistant cell lines of DU145 and LNCaP were compared to each other at the single gene level (a) and at the level of cancer-relevant gene annotation categories (b; categories: oncogenes (OG), tumor suppressor genes (TS), cancer census genes (CC), phosphatases (PH), kinases (KI), metabolic pathway gene (MG), signaling pathway gene (SG), transcriptional regulator (TR)). Significant overlaps between categories are denoted by ‘*’ (b; grey columns, P < 0.001, Fisher’s exact test). Identified under- (c) and overexpressed genes (d) were further mapped to known cancer-relevant signaling pathways. Overrepresented pathways were highlighted by ‘*’ (P < 0.05, Fisher’s exact test) and ‘**’ (P < 0.01).