Fig 2. Tumour growth after external beam radiotherapy and/or gemcitabine treatment.
GOT2-carrying nude mice were treated with 5 Gy external beam radiotherapy (EBRT) and/or 60 mg/kg gemcitabine twice weekly (Gem low). The absorbed dose and amount of gemcitabine were chosen to give low to moderate effect as single treatment to enable detection of any additive or synergistic effects. (A) Mean relative tumour volume (RTV) vs. time after first treatment. In addition to the measured values for each group, also the calculated relative tumour volume given a predicted additive response (Eq (2)) is shown. Error bars show SEM. A star indicate that the ANOVA analyses (performed at day 3–30) resulted in a statistically significant difference between the group means. (B) RTV vs. time after first treatment for each individual mouse. (C) Mean RTV for each group divided by mean RTV in the untreated control group (RTV/RTVcontrol) vs. time after first treatment. (D) Percentage of animals in each group without tumour progression vs. time after first treatment. Note differences in scale of the x-axis compared with Fig 1.