Table 1. GOT2-carrying nude mice were treated according to the presented schedules with 177Lu-octreotate (Lu), gemcitabine (Gem) and/or external beam radiotherapy (EBRT), or left untreated as control animals.
Administered amount: Lu (MBq), Gem (mg/kg) or EBRT (Gy) |
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Group | T (d) | Day 0 | Day 3 | Day 7 | Day 10 | Day 13 | n | F (d) |
Lu | 96 | 10 | 0 | 0 | 0 | 0 | 5 | 16 |
Gem high | 96 | 125 | 125 | 125 | 60 | 60 | 5 | 16 |
Lu + Gem high | 96 | 10+125 | 0+125 | 0+125 | 0+60 | 0+60 | 5 | 16 |
EBRT | 62 | 5 | 0 | 0 | 0 | 0 | 5 | 44 |
Gem low | 137 | 60 | 60 | 60 | 60 | 60 | 10 | 44 |
EBRT + Gem low | 62 | 5+60 | 0+60 | 0+60 | 0+60 | 0+60 | 6 | 58 |
Untreated control | 145 | - | - | - | - | - | 12 | 30 |
T, median time between transplantation and treatment start; n, number of animals in each group; F, follow-up time.