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. 2019 Nov 13;39(46):9130–9144. doi: 10.1523/JNEUROSCI.1683-19.2019

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Figure 5. — Activation of MCC Cg2^Glu to ZI^GABA circuit alleviates neuropathic pain. A, Optical activation of unilateral MCC Cg2^Glu alleviated neuropathic allodynia contralaterally. Sham and laser on daily n = 8/group, laser off and laser on once n = 10/group, one-way ANOVA with Tukey's post hoc; D7: F_(3,32) = 18.69, p < 0.001, laser off versus sham, p < 0.001, laser on daily versus laser off, p = 0.0202; D14: F_(3,32) = 18.01, p < 0.001, laser off versus sham, p < 0.001, laser on daily versus laser off, p = 0.0023. B, Optical activation of unilateral MCC Cg2^Glu induced place preference in neuropathic mice. n = 8/group, two-way ANOVA with repeated measures and Bonferroni's post-test (F_(2,58) = 7.314, p = 0.0015). PSL group, test versus preconditioning, p = 0.0219. C, Optical inhibition of unilateral MCC Cg2^Glu deteriorated neuropathic allodynia contralaterally. Sham n = 8, laser off, laser on once and laser on daily n = 10/group, one-way ANOVA with Tukey's post hoc; D7: F_(3,34) = 34.06, p < 0.001, laser off versus sham, p < 0.001, laser on daily versus laser off, p = 0.6463; D14: F_(3,34) = 75.97, p < 0.001, laser off versus sham, p < 0.001, laser on daily versus laser off, p = 0.0315. D, Optical inhibition of unilateral MCC Cg2^Glu induced place averseness in neuropathic mice. Sham n = 7, PSL n = 6, two-way ANOVA with repeated measures and Bonferroni's post-test (F_(2,46) = 3.214, p = 0.0494). PSL group, test versus preconditioning, p = 0.0122. E, Optical activation of ZI terminals of MCC Cg2^Glu alleviated neuropathic allodynia contralaterally. Sham n = 8, laser off n = 9, laser on once and laser on daily n = 7/group, one-way ANOVA with Tukey's post hoc; D7: F_(3,27) = 16.45, p < 0.001, laser off versus sham, p < 0.001, laser on daily versus laser off, p < 0.001; D14: F_(3,27) = 16.73, p < 0.001, laser off versus sham, p < 0.001, laser on daily versus laser off, p = 0.0360. F, Optical activation of ZI terminals of MCC Cg2^Glu induced place preference in neuropathic mice. Sham n = 6, PSL n = 7, two-way ANOVA with repeated measures and Bonferroni's post-test (F_(2,46) = 5.027, p = 0.0106). PSL group, test versus preconditioning, p = 0.0410. G, Optical activation of DLPAG terminals of MCC Cg2^Glu did not affect neuropathic allodynia. Sham n = 8, laser off n = 10, laser on once and laser on daily n = 8/group, one-way ANOVA with Tukey's post hoc; D7: F_(3,30) = 22.90, p < 0.001, laser off versus sham, p < 0.001; D14: F_(3,30) = 46.41, p < 0.001, laser off versus sham, p < 0.001. H, Optical activation of DLPAG terminals of MCC Cg2^Glu did not induce place preference in neuropathic mice. Sham n = 7, PSL n = 6, two-way ANOVA with repeated measures and Bonferroni's post-test (F_(2,46) = 1.826, p = 0.1725). *p < 0.05, ***p < 0.001, laser off versus sham. #p < 0.05, ##p < 0.01, ###p < 0.001, laser on daily versus laser off.