Skip to main content
. 2019 Nov 13;39(46):9130–9144. doi: 10.1523/JNEUROSCI.1683-19.2019

Figure 6.

Figure 6.

Activation of ZIGABA alleviates neuropathic pain. A, Flow chart of the experiment. B, Example photomicrograph for the site of cannula placement. Scale bar, 200 μm. C, Example ZI neuron that increased its firing frequency in response to blue laser stimulation. D, Daily optical activation of unilateral ZIGABA alleviated neuropathic allodynia contralaterally. Sham n = 10, laser off n = 8, laser on n = 7, one-way ANOVA with Tukey's post hoc; D7: F(2,22) = 24.46, p < 0.001), laser off versus sham, p < 0.001, laser on versus laser off, p < 0.001; D14: F(2,22) = 18.20, p < 0.001, laser off versus sham, p < 0.001, laser on versus laser off, p < 0.001. E, Optical activation of unilateral ZIGABA induced place preference in neuropathic mice. Sham n = 7, PSL n = 10, two-way ANOVA with repeated measures and Bonferroni's post-test (F(2,62) = 13.93, p < 0.001). PSL group, test versus preconditioning, p = 0.0012. **p < 0.01, ***p < 0.001, laser off versus sham. ###p < 0.001, laser on versus laser off.