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. 2019 Nov 14;8:e50482. doi: 10.7554/eLife.50482

Figure 3. Gene decoding of age-related changes in skewness against the Allen Institute for Brain Sciences gene expression atlas.

Only genes negatively relating to age-related changes in skewness are shown as only these genes survived FDR < 0.05. No other moments had any significantly associated genes. Cell-type-specific expression, showing selective enrichment for oligodendrocytes, reinforcing the link between profile skewness and myelination. Hexagon rings denote significance at different pSI thresholds (from p<0.05 in the outer ring to 0.00001 in the centre). (B) Developmental cortical enrichment, showing enrichment specifically in adolescence and young adulthood.

Figure 3.

Figure 3—figure supplement 1. Gene ontology analyses from baseline profiles of the four moments of the intensity distribution.

Figure 3—figure supplement 1.

Results from this spatial overlap analysis show no clear or unique ontological profile for any of the genes and when p-values were corrected for FDR across the four moments and positive and negative gene-lists, none survived correction.