Skip to main content
. 2019 Nov 14;8:e50766. doi: 10.7554/eLife.50766

Figure 8. Arginines involved in POPG binding and ELIC desensitization.

Figure 8.

(A) Top view of ELIC highlighting TM4 (yellow) and showing the side chains of R117, R123, and R301 (magenta) adjacent to TM4, which increase ELIC desensitization, and R286 at the subunit interface (salmon), which has no effect on desensitization. The L238 side chain is shown in red. (B) Image from coarse-grained simulations with 50% POPG showing two adjacent ELIC subunits and the mutated arginine side chains (R117, R123, R299, and R301 in magenta; R286 in salmon). Also shown are all POPG lipids making contacts with the TMD in this snapshot.