| A.Upregulated |
| Pathway ID |
Name |
P-value |
Count |
Genes |
| hsa04110 |
Cell cycle |
4.44 × 10−6
|
8 |
CCNB1, CDC6, CCNB2, MAD2L1, BUB1, TTK, BUB1B, CDC20 |
| hsa04114 |
Oocyte meiosis |
2.24 × 10−2
|
4 |
CCNB2, MAD2L1, BUB1, CDC20 |
| hsa04914 |
Progesterone-mediated oocyte maturation |
1.20 × 10−2
|
4 |
CCNB1, CCNB2, MAD2L1, BUB1 |
| hsa03460 |
Fanconi anemia pathway |
3.19 × 10−2
|
3 |
FANCI, BRIP1, UBE2T |
| B.Downregulated |
| Pathway ID |
Name |
P-value |
Count |
Genes |
| hsa04261 |
Adrenergic signaling in cardiomyocytes |
5.87 × 10−6
|
12 |
AGTR1, ADRB2, ADRB1, PLCB4, TNNC1, KCNE1, ADRA1A, SCN4B, RAPGEF4, SCN7A, ATP1A2, CACNA2D2 |
| hsa04080 |
Neuroactive ligand-Receptor interaction |
2.73 × 10−3
|
12 |
EDNRB, AGTR1, ADRB2, S1PR1, ADRB1, RXFP1, SSTR1, GRIA1, ADRA1A, CALCRL, NPY1R, VIPR1 |
| hsa04024 |
cAMP signaling pathway |
2.30 × 10−2
|
10 |
FXYD1, ADRB2, ADRB1, SSTR1, GRIA1, NPR1, RAPGEF4, HHIP, ATP1A2, NPY1R |
| hsa04022 |
cGMP-PKG signaling pathway |
2.43 × 10−3
|
9 |
EDNRB, AGTR1, ADRB2, ADRB1, PLCB4, PDE5A, ADRA1A, NPR1, ATP1A2 |
| hsa04270 |
Vascular smooth muscle contraction |
1.77 × 10−3
|
8 |
RAMP3, RAMP2, AGTR1, PLCB4, PLA2G1B, ADRA1A, NPR1, CALCRL |
