Figure 8.

In vivo effect of Tegavivint on metastatic potential of the ALDH1^high population of TCCC-OS84 cells. A) Schema of experimental approach with tail vein injection of ALDH1^low or ALDH1^high populations of TCCC-OS84 lung cells and subsequent treatment with Tegavivint is shown. B) Representative hematoxylin and eosin-stained lung sections from each cohort are shown. Scale bar = 200 µm. C) Average number of pulmonary nodules per three randomly selected sections was quantified per mouse (four mice/cohort). Comparison of the ALDH1^high without Tegavivint cohort to the other cohorts was performed. Data are shown as median with 95% confidence interval. Wilcoxon rank sum test was used to determine statistical significance.