Table 1.
Linkage-nonspecific sialic acid derivatization
| Nucleophile | Condensing reagents or main reagents | Sialic acid derivative | Reaction condition | Publication |
|---|---|---|---|---|
| — | CH3I, DMSO | Methylester | Room Temp., 2 hours | Powell et al., 199631) |
| Ammonium chloride (NH4Cl) | DMT-MM | Amide | 50 ℃, 24 hours | Sekiya et al., 200533) |
| — | MTT | Methylester | 50 ℃, 1∼2 hours | Miura et al., 200732) |
| Acetohydrazide | EDC (pH 2.5) | Amidation by acetohydrazide | Room Temp., 2 hours | Toyoda et al., 200834) |
| Methylamine chloride | PyAOP, NMM | Methylamide | Room Temp., 30 minutes | Liu et al., 201037) |
| p-Toluidine | EDC (pH 4.5) | Amidation by p-toluidine | Room Temp., 4 hours | Shah et al., 201336) |