Table II.

Average ACV Amounts Recovered from the SC After Uptake and Clearance (Q_Up and Q_Cl, Respectively), the Deduced Drug Flux from the SC into the Underlying Viable Tissue During the Clearance Period (J_{in vivo}), and the First-Order Rate Constant (k) Describing Clearance from the SC^a

	Study 1				Study 2
	US-Ref	US-C+	UK-Test	US-Ave	AT-Ref	AT-C+	US-Test	AT-Ave
QUp (μg/cm2)	0.68 (0.49–0.95)	0.59 (0.46–0.77)	0.42 (0.31–0.57)	0.64 (0.48–0.85)	1.54 (1.09–2.19)	1.74 (1.11–2.73)	0.96 (0.76–1.22)	1.64 (1.11–2.42)
QCl (μg/cm2)	0.45 (0.34–0.59)	0.42 (0.32–0.57)	0.26 (0.17–0.38)	0.43 (0.33–0.56)	1.69 (1.24–2.30)	1.45 (1.04–2.03)	0.85 (0.65–1.11)	1.50 (1.24–2.13)
Jin vivo (ng/cm2/h)	18 ± 12	9.9 ± 8.2	9.6 ± 8.0	14 ± 8.6	−8.0 ± 37	27 ± 25	6.2 ± 17	9.6 ± 24
102 k (h−1)	2.5 ± 1.2	2.0 ± 1.7	2.8 ± 2.2	2.3 ± 1.2	−0.5 ± 1.7	1.0 ± 1.2	0.7 ± 1.6	0.3 ± 1.2

^aQ_Up and Q_Cl are reported as the anti-logarithm of the arithmetic mean (lower-upper 90% confidence interval) of the log-transformed values; J_{in vivo} and k are the arithmetic means (lower-upper 90% confidence intervals); n = 10. Values for US-Ave and AT-Ave were calculated using the geometric mean of 4 replicates (from Ref and C+ combined) for Q_up and Q_Cl in each subject