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. 2019 Jun 25;58(11):1355–1371. doi: 10.1007/s40262-019-00790-0

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 3 — Impact of changing of CL_int and multiplicative factor for K_p factors on the intravenous PK profile. As CL_int is increased, the profile shifts down, with the shape remaining intact. The effect of increasing the K_p factor is to change the shape of the profile. CL_int intrinsic clearance, K_p tissue partition coefficient, PK pharmacokinetic, IV intravenous, PBPK physiologically based pharmacokinetics