. 2019 Feb 21;37(6):1207–1217. doi: 10.1007/s10637-019-00732-4

Table 2.

Dose-limiting toxicity

Regimen	Dose	Number of DLT evaluable patients	Number of patients who experienced a DLT	DLT	Grade
QD	4 mg/day	3	0	–	–
	8 mg/day	6	0	–	–
	10 mg/day	6	1	Drug-induced liver injury	G3
	12 mg/day	3	2	Platelet count decreased	G4
	12 mg/day	3	2	Urticaria	G3
	16 mg/day	3	2	Urticaria	G3
	16 mg/day	3	2	Interstitial lung disease^a	G3
BID	8 mg/day	6	1	Interstitial lung disease^a	G3
	12 mg/day	5	2	Interstitial lung disease^a	G3
				Platelet count decreased	G3
				Left ventricular failure	G3

BID twice daily, DLT dose-limiting toxicity, QD once daily

^aInterstitial lung disease included lung disorder and pneumonitis