Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Results of pathogenicity prediction programs for MIT domain sequence changes identified in HSP patients.
| Mutation | SIFT prediction (score) | PolyPhen prediction (score) |
|---|---|---|
| E112K | Tolerated (0.74) | Benign (0.017) |
| R115C | Deleterious (0.02) | Benign (0.251) |
| N184T | Deleterious (0) | Probably damaging (1) |
| L195V | Deleterious (0) | Possibly damaging (0.823) |
