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a, TM domain structure in one subunit, viewed from membrane (left) or intracellular side (right). b, Slab view of one TM domain showing partially inward-open conformation. Surface coloured by electrostatic potential (red, −5 kT e−1; blue, +5 kT e−1). c, Lipids and dimer of TMDs, viewed from intracellular side. d, Ordered lipid molecules at dimer interface. Densities attributed to lipids shown as blue meshes.
