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. Author manuscript; available in PMC: 2020 Feb 1.
Published in final edited form as: Nature. 2019 Jul 31;572(7770):488–492. doi: 10.1038/s41586-019-1438-2

Figure 5 |. Disease-related mutations and interconnected ion-binding sites.

Figure 5 |

a, Mutations on NCC linked to Gitelman syndrome mapped onto the structure through sequence alignment. Mutations are shown as spheres and grouped into six categories: ion translocation pathway (purple), cap domain (blue), TM domain dimer interface (green), TM-soluble interface (red), CTD dimer interface (cyan), and structural/folding (yellow) mutations. Other mutations in grey. b, Schematic of ion-binding sites: coordination, dashed lines; core domain helices, light blue; and scaffold domain helices, yellow.