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. 2019 Nov 14;9:16746. doi: 10.1038/s41598-019-53196-0

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Functional annotations of up-regulated and down-regulated proteins in 3D co-cultured adipocytes with macrophages compared to those in the 2D mono-cultured adipocytes using the PANTHER classification system and STRING. (A) Molecular function, (B) biological process, (C) cellular component, (D) KEGG pathway. For the classification of quantified proteins, 124 up-regulated and 67 down-regulated proteins from a total of 2,885 quantified proteins were used. The red and blue rods show the percentage (%) and –log FDR value of up-regulated and down-regulated proteins, respectively. The KEGG pathways for the up-regulated and down-regulated proteins are listed in Supporting Table 2.