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. 2019 Nov 14;9:16775. doi: 10.1038/s41598-019-53290-3

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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LMI detects changes in differentiation status in known examples of differentiation. (a) LMIs of distinct human myeloid cells along the developmental stages from the most immature stem cells to the mature granulocytes. (b) LMI analysis of APL leukemia (NB4 cells) treated with ATRA for 72 hours. (c) LMIs for the drugs from GE-HTS project. The Student’s t test for each drug treatment compared to DMSO controls is shown in Supplementary Table S1. The dashed line indicates the p value cut off at 0.05.