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. 2019 Nov 14;9:16761. doi: 10.1038/s41598-019-53384-y

Figure 3.

Figure 3

Clinical impact of the CRPC N-glycan score on CRPC discrimination. The Waterfall plots show the association between the CRPC N-glycan score and the CRPC status (A). The CRPC N-glycan score was significantly greater in patients with CRPC than in those with BPH, newly diagnosed PC, and PC with ADT (B). The predictive value of the N-glycan score for CRPC was significant, with an area under the curve (AUC) of 0.88 (95% CI = 0.83–0.93, P < 0.001) (C). The CSS (from serum N-glycan analysis until death) were significantly shorter in CRPC patients with higher CRPC N-glycan score (>1.7 points) than in those with lower scores (≤1.7 points) (D; P = 0.028). The longitudinal evaluation of the CRPC N-glycan score showed the CRPC N-glycan score was greater before-and-after CRPC (n = 5) than that at the baseline (E; P = 0.048).