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. 2019 Nov 14;9:16744. doi: 10.1038/s41598-019-53351-7

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Immunohistological characteristics of types I, III, and V collagen in control and remote vs. scar within the healing period of 28 days post-MI. Spatial distribution of type I collagen in remote (A-left) and scar (A-right), type III collagen in remote (B-left) and scar (B-right), and type V collagen in remote (C-left) and scar (C-right) control (upper panels). Scale bar: 50 μm. Time variation of the amount of types I, III, and V collagen in remote (D–F) and in scar (G–I). The collagen amount is normalized by the total amount of type I, III, and V collagen in remote and scar. (*p < 0.5, ***p < 0.001, ****p < 0.0001).