Figure 4.

Study on the role of TNFR1 in endothelium, gut epithelium, and hepatocytes using conditional knock-out mice in the cecal ligation and puncture model. Male TNFR1^flox/flox and cell-specific conditional TNFR1^−/− mice were subjected to CLP. Survival was monitored for 10 days in (A) endothelium (TNFR1^Tie2−KO) (n = 8), (B) gut epithelium (TNFR1^Villin−KO) (n = 12) and (C) hepatocyte (TNFR1^Alb−KO) specific (n = 12) knockout mice, and compared with TNFR1^flox/flox mice (n = 9, 13, and 10, respectively).