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. 2019 Nov 14;9:16842. doi: 10.1038/s41598-019-53312-0

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Plasma concentrations of TRP-derived metabolites in abstinent CUD-patients according to diagnosis of comorbid mental disorders. Plasma concentrations of (a) TRP, (b) KYN, (c) KA, (d) QA and (e) 5-HT were determined in the non-comorbid subgroup and the comorbid subgroup (common mental disorders: mood disorders, anxiety, psychotic disorders and personality disorders). Bars are estimated marginal means and 95% CI. Data were analyzed by ANCOVA. (**)p < 0.01 denotes significant differences compared with the non-comorbid subgroup. Dashed lines indicate marginal means of the control group.